Aggressive Breast Cancer - download pdf or read online

By Regina H. DeFrina

ISBN-10: 1617618640

ISBN-13: 9781617618642

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Elucidating the molecular changes that occur as tumors progress on anti-HER2 therapy will allow the design of novel targeted therapies. Additionally, new HER2 targeting strategies are in preclinical and clinical development stages. REFERENCES Jemal, A; Siegel, R; Ward, E; Hao, Y; Xu, J; Murray, T; Thun, MJ. Cancer statistics, 2008. , 2008, 58, 71-96. Slamon, DJ. Proto-oncogenes and human cancers. N Engl J Med, 1987, 317, 955957. The HER2 Oncogene in Breast Cancer 37 Hudis, CA. Trastuzumab--mechanism of action and use in clinical practice.

Retrospective, multivariate analysis of data from 47 studies involving more than 15,000 patients confirmed that, in the majority (60%) of studies and the majority (67%) of patients, a HER2positive status was an independent predictor of a worse prognosis in node-positive patients[48]. Studies evaluating HER2 status and prognosis in node-negative patients, however, have yielded conflicting results [48]. The reliability and comparability of these studies are limited by a number of factors, including evaluation of small numbers of patients, inconsistencies in post-surgical treatment and in the methods used for the assessment of HER2 status.

Culture of MCF7 cells with either tamoxifen or the anti-estrogen fulvestrant (Faslodex® AstraZenica) has been shown to generate cell sublines which tolerate the presence of these agents, and grow at rates equivalent to their parental lines [63, 64]. Under these circumstances of antiestrogen resistance, parallel increases in EGFR/HER1 and HER2 protein have been observed. In addition sensitization to the effects of the EGFR tyrosine kinase inhibitor, gefitinib (Iressa® AstraZeneca), have also been reported [65].

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Aggressive Breast Cancer by Regina H. DeFrina


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